Giving New Identities to Alveolar Epithelial Type I Cells
نویسندگان
چکیده
منابع مشابه
Modification of type I collagenous gels by alveolar epithelial cells.
Contraction of type I collagen gels is an in vitro model of tissue remodeling. In addition to fibroblasts, some epithelial cells can mediate this process. We therefore hypothesized that alveolar epithelial cells might contract extracellular matrices and have the potential to directly participate in the remodeling of the lung after alveolar injury. A549 cells were plated on top of collagen gels,...
متن کاملEndocytic response of type I alveolar epithelial cells to hypertonic stress.
We present plasma membrane (PM) internalization responses of type I alveolar epithelial cells to a 50 mosmol/l increase in tonicity. Our research is motivated by interest in ATI repair, for which endocytic retrieval of PM appears to be critical. We validated pharmacological and molecular tools to dissect the endocytic machinery of these cells and used these tools to test the hypothesis that osm...
متن کاملPotential contribution of alveolar epithelial type I cells to pulmonary fibrosis
Pulmonary fibrosis (PF) is characterized by inflammation and fibrosis of the interstitium and destruction of alveolar histoarchitecture ultimately leading to a fatal impairment of lung function. Different concepts describe either a dominant role of inflammatory pathways or a disturbed remodeling of resident cells of the lung parenchyma during fibrogenesis. Further, a combination of both the mec...
متن کاملPotential Contribution of Type I Alveolar Epithelial Cells to Chronic Neonatal Lung Disease
The alveolar surface is covered by large flat Type I cells (alveolar epithelial cells 1, AEC1). The normal physiological function of AEC1s involves gas exchange, based on their location in approximation to the capillary endothelium and their thinness, and in ion and water flux, as shown by the presence of solute active transport proteins, water channels, and impermeable tight junctions between ...
متن کاملAlveolar Epithelial Ion and Fluid Transport Na transport proteins are expressed by rat alveolar epithelial type I cells
Borok, Zea, Janice M. Liebler, Richard L. Lubman, Martha J. Foster, Beiyun Zhou, Xian Li, Stephanie M. Zabski, Kwang-Jin Kim, and Edward D. Crandall. Na transport proteins are expressed by rat alveolar epithelial type I cells. Am J Physiol Lung Cell Mol Physiol 282: L599–L608, 2002; 10.1152/ajplung.00130.2000.—Despite a presumptive role for type I (AT1) cells in alveolar epithelial transport, s...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: American Journal of Respiratory Cell and Molecular Biology
سال: 2017
ISSN: 1044-1549,1535-4989
DOI: 10.1165/rcmb.2016-0383ed